CG 428
CG 428 is in Phase 2 for chemotherapy-induced alopecia, developed by Legacy Healthcare.
A Legacy Healthcare botanical lotion trialled during chemotherapy and, in a published pilot, in persistent post-chemotherapy hair loss, with nothing registered since 2019.
This programme is no longer being actively pursued.
- Developed by
- Legacy Healthcare
- Current phase
- Phase 2
- Mechanism
- Undisclosed
- Indications
- Chemotherapy-induced alopecia
- Last public activity
- August 2019
- Copy last reviewed
- September 2026
- Record confidence
- Low
Tests whether it works, at what dose, in a few hundred people.
The sponsor has not said how it is supposed to work.
A research record, not medical advice: being listed here says nothing about whether a treatment works or whether it is right for you. Talk to a dermatologist about your own case.
Why it matters
Hair that does not come back after chemotherapy is a distinct problem from hair lost during it, and little is developed for it. CG428, a blend of citrus, cocoa, guarana and onion extracts, was tested both ways: Legacy's own Phase 2 in Switzerland, 40 women losing hair during chemotherapy, completed in 2019 without posting a result, and an academic pilot at Samsung Medical Center in 32 breast-cancer survivors with permanent loss found no significant difference from placebo in density or thickness, published in 2019. Nothing has been registered since. Legacy already appears in this register for Coacillium, a four-extract solution of similar composition; the two rows stay separate because the registrations do.
Development history
- Phase 2
First Phase 2 trial on record: NCT02919735 — Efficacy, Safety and Tolerability of CG428 Cutaneous Solution on Chemotherapy Induced Alopecia; Controlled Study (ELAN)
ClinicalTrials.gov ↗
Registered trials
Pulled automatically from ClinicalTrials.gov. Matching is by name and development code, so occasional gaps are possible — tell us if you spot one.
Efficacy, Safety and Tolerability of CG428 Cutaneous Solution on Chemotherapy Induced Alopecia; Controlled Study (ELAN)
Legacy Healthcare SA · n=40 · October 2016
EValuation of the Impact of a TOpical Lotion on Permanent Chemotherapy Induced Hair Disorders in Cancer Survivors
Samsung Medical Center · n=32 · July 2016
A 6-month Post-interventional Follow-up Extension of VOLUME Study (VOLUME-2)
Samsung Medical Center · n=19 · January 2016
Listing a trial is not a recommendation to join one. Eligibility, risks and costs vary enormously — discuss any trial with your own doctor first.
Sources
- CG 428 cutaneous solution in chemotherapy-induced alopecia — ClinicalTrials.gov
- Evaluation of the Impact of a Topical Lotion on Permanent Chemotherapy Induced Hair Disorders in Cancer Survivors (VOLUME) — ClinicalTrials.gov
- Impact of a topical lotion (CG428) on permanent chemotherapy-induced alopecia in breast cancer survivors: a pilot randomised trial, Kang et al. — Peer-reviewed, July 2019
Related programmes
Other programmes in the register with the same approach.
Home remedies that mention it
- Does onion juice regrow hair?
One small 2002 study in alopecia areata, with no repeat we could find. Nothing in pattern baldness.
Cite this page
Hair Pipeline, "CG 428 — development record", hairpipeline.com/pipeline/cg-428